NamuPlex™ HLA-DRB1 NGS typing Kit : NGS

NamuPlex™
HLA-DRB1 NGS typing Kit

Cat. GNT-4009-1

Korea MFDS

HLA is a major antigenic system in determining the survival of transplant allografts or transfused platelets in sensitized individuals. HLA class I antibodies can be formed after blood transfusions, after organ transplantations and during pregnancy. HLA molecules play a key role in immunity and recognition of self versus non-self, consequently HLA typing and HLA matching is mandatory prior to most forms of transplantation. As HLA antigens restrict the specificity of T-cell mediated immune responses HLA typing can also be a useful investigative tool in any immune disorder or any immune response to pathogens, vaccines or medical treatment. HLA typing can also be used to support disease diagnosis where certain HLA alleles have been shown to be significantly associated with disease states.

Intended Use

The NamuPlex™ HLA-DRB1 NGS typing Kit is an in vitro diagnostic test that identifies HLA-DRB1 alleles at high resolution among Human Leukocyte Antigens (HLA) using DNA extracted from the transplant donor’s or recipient’s whole blood samples. It uses PCR (Polymerase Chain Reaction) and NGS (Next Generation Sequencing) methods to support qualitative testing of histocompatibility genes for bone marrow or organ transplants.